In order to find a loophole in the tightening restrictions on vapes, Chinese vape manufacturers came up with a new idea: put a nicotine analogue in e-liquid. As a result, Nixodine vapes were developed. This blog focuses on what is nixodine, is nixodine safe and an expanding list that includes nixodine vapes, e-liquid and brands that manufacture them.
Table of Contents
1. What is Nixodine?
Nixodine is a mixture of nicotinamide and the nicotine analogue 6-MN. Nicotinamide (NA) is a form of vitamin B3. NA has no known pharmacological activity at nicotinic acetylcholine receptors and generally does not produce effects similar to nicotine. The nicotine analog, 6-MN, is the main active ingredient.
6-MN is also known as 6-methyl nicotine. It is an analog of nicotine with similar structure. 6MN was synthesized by chemically modifying nicotine in 1967. In the 1980s, Philip Morris studied the chemistry of 6-MN and did not decide to replace nicotine with it in cigarettes.
2. Nixodine vs Nicotine
Nicotine is a well-known, highly addictive chemical and to blame for the form of smoking habit. It is also often mistakenly considered a carcinogen, although it is not one. Through decades of study, we understand both the negative and positive effects of nicotine. As to nixodine, we barely know its formulation. The table below compares Nixodine with nicotine:
| Feature | Nixodine | Nicotine |
|---|---|---|
| What it is | A marketed nicotine alternative; its composition may vary | A naturally occurring tobacco alkaloid |
| Main ingredients | May contain nicotinamide, 6-MN, or both, depending on the product | Nicotine |
| Chemical status | Usually marketed as nicotine-free, although some formulations may contain 6-MN, a nicotine analogue | The actual nicotine molecule |
| Product formats | E-cigarettes, e-liquids, and some oral pouch products | Cigarettes and other tobacco products; nicotine patches, nicotine pouches, nicotine gum, nicotine strips, e-cigarettes, and e-liquids |
| Nicotinic receptor activity | Nicotinamide has no known activity at nicotinic receptors. 6-MN can activate these receptors and may be more potent than nicotine in some animal studies | Activates nicotinic acetylcholine receptors in the brain and nervous system |
| Nicotine-like effects | Cannot be assumed; effects depend on whether 6-MN is present and how much the product contains | Well-established stimulant and reinforcing effects |
| Addictiveness | Unknown for nicotinamide; potentially significant if 6-MN is present | Well-established as addictive |
| Safety evidence | Limited evidence exists on inhaled use and long-term effects | More extensively studied, although nicotine remains addictive and carries health risks |
| Legal status | Not uniformly regulated; regulation may be unclear or still developing, depending on the jurisdiction and formulation | Generally regulated, with strict restrictions often applying to sales, marketing, age, labeling, and product composition |
In short, nixodine, with its prominent ingredient 6-methyl nicotine, lacks research and could be more addictive than nicotine.
3. Is Nixodine Safe?
In 2024, one of the suppliers of nicotine alternative products marketed as nixodine, nixamide and other brand names updated its page for nicotine alternative and stated that Nixodine is a combination of nicotinamide and the nicotine analog 6MN. Nixodine is a product family/brand other than a chemical with a fixed formulation. Let’s assume that nixodine is a mixture as Nicotine River states and evaluate the two known ingredients separately.
(1) Is Nicotinamide (NA) Safe to Vape?
The safety of nicotinamide for vaping is little known compared with nicotine. E-juice is vaporized and inhaled in the form of aerosol. Although nicotinamide is a form of vitamin B3, it doesn’t mean it is safe to vape. A report in Chemical Research in Toxicology on March 31, 2026 mentioned that 3-CP is a byproduct when NA is vaporized at the working temperature of e-cigarettes. 3-CP shows lung toxicity, which indicates the potential harm brought by NA vaporization.
(2) Is 6MN Safe to Vape?
There is no evidence for the safety of 6MN use for vaping. It is concerning as the US vape market is filled with vapes and e-juice containing 6MN and nicotine analogs. With extremely thin human evidence, I can safely conclude that 6-methyl nicotine is nicotine-like and produces similar or stronger effects than nicotine. 6MN is potentially addictive and not safer than nicotine.
(3) What is 6MN (6-methyl nicotine)?
6-methyl nicotine, short for 6MN, is a structural nicotine analog. Since the 1970s, the tobacco industry has conducted studies on the nicotine analogs, including 6MN. It is expected to replace nicotine in the face of regulations in the future. However, nicotine analogs have never been commercialized until now. And it’s more and more common in states with vape bans, such as Virginia.
4. Updating Nixodine Vape List and Other Products
After seeing reports from Reddit about possible discomfort caused by nicotine analog in ejuice and disposable vapes, I’d like to make a list of these products for vapers who might be misled into choosing unwanted products. This nixodine vape list also includes nicotine analog of other brand names. You can check the brand name, product name, nicotine analog type and one picture of the package here.
| Brand Name | Product Type | Product Name | Nicotine Analog Type | Package Photo |
|---|---|---|---|---|
| OXBAR | Disposable Vape | OXBAR Maglink 75K | Nixodine |
|
| Lyco | Disposable Vape | Lyco Mini Box 50K | Nixodine |
|
| Bloow | Disposable Vape | Bloow Bubble 65K | Nixodine |
|
| Fasta | Disposable Vape | Fasta Drop 50K | Nixodine |
|
| Fifty Bar | Disposable Vape | Fifty Bar 20K Nixodine EDN | Nixodine |
|
| Fasta | Disposable Vape | Fasta 40K Nixodine | Nixodine | |
| PARFFLO | Disposable Vape | PARFFLO Hookah Blast 40K | Nixodine |
|
| Fogertech | Disposable Vape | Foger Switch Pro 30k Nixodine | Nixodine |
|
| Lala Bar | Disposable Vape | Lala Bar Vibe 40K Nixodine EDN | Nixodine |
|
| Juice Head | Disposable Vape | Juice Head iFlex 50K Nixodine | Nixodine |
|
| Lost Mary | Disposable Vape | Lost Mary MT35000 Turbo Nixodine Edition |
|
|
| YOVO | Disposable Vape | YOVO JB50K Nixodine | Nixodine |
|
| RinnBar | Disposable Vape | RinnBar 50K Nixodine | Nixodine |
|
| HIDI | Disposable Vape | HIDI Max 50K | 6MN (6-methyl nicotine) |
|
| Navabar | Disposable Vape | Navabar 55K | "Ultra 6" (Poss.6MN) |
|
| Gold Bar | Disposable Vape | Gold Bar Max 50K | Nixodine | |
| Well Versed | Disposable Vape | Kumi Six Oro 50K | SFN: NONIC6 (Poss.6MN) |
|
| Well Versed | Disposable Vape | Kumi Six Scenic 50K | SFN: NONIC6 (Poss.6MN) |
|
| Pyne Pod | Disposable Vape | Pyne Pod Click 80K | Nex6 (Unknown) |
|
| Hotbox | Disposable Vape | Hotbox Elite 50K | Nixodine |
|
| SBX | Disposable Vape | SBX 25K | Metatine (6MN) |
|
| Spree Bar | Disposable Vape | Spree Bar 6000 | Metatine (6MN) |
|
| Rifbar | Disposable Vape | Rifbar MixPro 40K | Nixodine |
|
| Geek Labs | Disposable Vape | Geek Labs Switch Pro | Nixodine |
|
| Geek Labs | Disposable Vape | Geek Labs Pulse X 50K | Nixodine |
|
| Arc | Disposable Vape | Arc Hypertine 35K | Hypertine |
|
| Hazey | Disposable Vape | Hazey 25K Cloud 6 | Cloud 6 (6MN) |
|
| Pod Juice | E-liquid | Pod Juice Mint Series Nixodine 30ml | Nixodine |
|
| Pod Juice | E-liquid | Pod Juice X RAZ Gush 100ml | Nixodine |
|
| Keep it 100 | E-liquid | Keep it 100 Nixodine 30ml/100ml | Nixodine |
|
| Diip | Nicotine Pouch | Diip Nixodine Pouch | Nixodine |
|
| STRYK | Nicotine Pouch | STRYK | Nixodine |
|
5. How to Identify a Nixodine Vape?
From the product list, we can see most nixodine vapes are not produced by reliable manufacturers. Most of them are white-label products with the models of A and E-juice of B. You can hardly expect after-sales service from these “brands”.
It takes effort to identify nixodine vapes, especially when you buy vapes online, where pictures are limited. Here are three tells of nixodine vapes that help you avoid them. Follow this guide and you can identify nixodine vapes and products with ease.
(1) Different Health Warning Label
Nicotine Vapes/E-liquid: This product contains nicotine. Nicotine is an addictive chemical. (US) / This product contains nicotine, which is a highly addictive substance. (UK)
Nicotine Analog: This product is intended for adults (only). This product may be addictive/habit-forming. Do not use if you are pregnant or nursing.
The health warning label for nixodine vapes are more ambiguous and does not mention nicotine. Real nicotine-free vapes come with simpler labels, such as “Zero Nicotine” or “This product does not contain nicotine”.
(2) Nixodine Trademark
Manufacturers who want to label their products with Nixodine need to pay for this blue trademark. If you see this big N trademark, think twice.
(3) Check the specifications
On the back of the package, check the ingredients. X% nicotine is the normal case. Made-up words like “nixotine” or “nex6” before percentage are signs of nicotine analog.
6. Adverse Effects of Nixodine (6MN)
Despite the lack of human research, 6MN may be more potent and thus potentially more addictive than nicotine. A few Reddit posts also mention awful side effects like nausea, dizziness and increased heart beats.
For some vapers, they can’t handle their withdrawal symptoms with nixodine vapes. As the MOD wisely recommended in the post of subreddit “disposablevapes_“, be on the lookout for Nixodine/NoNic6/Metatine/Nixamide/6-MN and other nicotine substitutes.
7. Conclusion
Nixodine is not anything new but old wine in a seemingly new bottle. It was developed to exploit a loophole and evade tobacco taxes, but it is now marketed by Chinese vape manufacturers as being unregulated by the FDA. However, there is a lack of research on 6MN and so-called nicotine analogs. For your health, choose nicotine vapes or nicotine pouches instead. 6MN or nixodine, no matter how the brand name changes, is not a safe alternative to nicotine.
